노인 환자에 있어서 Bisphosphonate-related osteonecrosis of the jaw (BRONJ)
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) in old patients
권태건,
소속 상세정보
권태건 ( Kwon Tae-Geon ) - 경북대학교 치의학전문대학원 구강악안면외과학교실
KMID : 1033920120080010015
Abstract
Recent increase in old patients with bisphosphonate (BP) use greately influence the incidence ratio of Bisphosphonaterelated Osteonecrosis of the jaws (BRONJ). In Korea, life expectancy in female patient is gradually increasing and risk of postmanauposal osteoporosis is now one of the major nation-wide health problem. Because the Bisphosphonate is potent and efficient drug for osteoporosis, malignant bone tumor and metastatic bone disease, it is needed to prescribe this medicine for many patients even though we know the potential risk of jaw necrosis in long term coverage of the medicine. Various researches had proposed that the BRONJ is related with over-supression of osteoclastic activity and resultant problem in bone turnover. Other factors such as anti-angiogenesis, uncoupling of osteoblast-osteoclast equilibrium and jaw-specific microenvironment was suggested conttributing factors. Because the drug effect last longer than any other medicine, comphrehensive understanding of pathophysiology of the BRONJ is needed. Further clinical and basic research should be continued.
키워드
Bisphosphonate; Jaw; Necrosis
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